Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS)
detection have had a large impact on the development of new pharmaceuticals in the past …

Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs),
therapeutic drug monitoring (TDM) can make a significant contribution to the field of …

Abstract Microsampling, a reduced volume (< 50 μl) sampling method has successfully
gained attention at the International Conference on Harmonization (ICH) level. It has been …

Conventional sampling of biological fluids often involves a bulk quantity of samples that are
tedious to collect, deliver and process. Miniaturized sampling approaches have emerged as …

Dried blood spots (DBS) sampling and their specific advantages are becoming common in
analytical and clinical routine. Being first established for metabolic disorder screening in …

Currently, the growing demand on quick, easy and ecological sample pretreatment methods
is unquestionable. Such challenge involves also approaches focusing on the analysis of …

The review presents data from the last few years on bioanalytical methods used in
therapeutic drug monitoring (TDM) of the 1st–3rd generation and the newest antiepileptic …

Anti‐epileptic drugs (AEDs) have various pharmacokinetic profiles, inter‐individual
variabilities, high possibilities of drug‐drug interactions and narrow therapeutic indices. To …

In recent years, scientific researchers have increasingly become interested in noninvasive
sampling methods for therapeutic drug monitoring and disease diagnosis. As a result, dried …

Pregabalin has become more widely prescribed and abused in recent years but is still not
always included in laboratory analysis. An LC‐MS‐MS method has been developed and …