Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological
angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however …

Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-
interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed …

Formation of the premetastatic niche is triggered by primary tumors and contributes to
cancer metastasis. Evidence indicating the roles of macrophages in metastatic niche …

Retinal neovascularization, or pathological angiogenesis in the retina, is a leading cause of
blindness in developed countries. Transforming growth factor-β-activated kinase 1 (TAK1) is …

Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to
migrate through the endothelial layer of blood vessels to escape the hostile circulation and …

Abstract The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed
in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In …