Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted …
M Liao, R Qin, W Huang, HP Zhu, F Peng… - Journal of Hematology & …, 2022 - Springer
Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …
Anticancer compounds based on isatin-derivatives: Strategies to ameliorate selectivity and efficiency
RE Ferraz de Paiva, EG Vieira… - Frontiers in molecular …, 2021 - frontiersin.org
In this review we compare and discuss results of compounds already reported as anticancer
agents based on isatin-derivatives, metalated as well as non-metallated. Isatin compounds …
agents based on isatin-derivatives, metalated as well as non-metallated. Isatin compounds …
Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines
The current study investigated the cytotoxic effect of ten sulfonamide-derived isatins,
following molecular hybridization, based on the association principles, on hepatocellular …
following molecular hybridization, based on the association principles, on hepatocellular …
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
ZX He, YP Gong, X Zhang, LY Ma, W Zhao - European journal of medicinal …, 2021 - Elsevier
Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …
way to human health. Pyridazine featuring advantageous physicochemical properties and …
Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents via carbonic anhydrase IX inhibition
Changes in gene expression cause uncontrolled cell proliferation and consequently tumor
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene) thiazolidin-2-ylidene) amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity …
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
A Sabt, OM Abdelhafez, RS El-Haggar… - Journal of enzyme …, 2018 - Taylor & Francis
Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted …
Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
In connection with our research program on the development of novel anti-tubercular
candidates, herein we report the design and synthesis of two different sets of indole …
candidates, herein we report the design and synthesis of two different sets of indole …