Immune responses to Neisseria gonorrhoeae and implications for vaccine development

T Belcher, CS Rollier, C Dold, JDC Ross… - Frontiers in …, 2023 - frontiersin.org
Neisseria gonorrheoae is the causative agent of gonorrhea, a sexually transmitted infection
responsible for a major burden of disease with a high global prevalence. Protective …

Recent progress towards a gonococcal vaccine

SA Maurakis, CN Cornelissen - Frontiers in cellular and infection …, 2022 - frontiersin.org
Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly
acquires antimicrobial resistance and does not confer protective immunity as a …

BauA and Omp34 surface loops trigger protective antibodies against Acinetobacter baumannii in a murine sepsis model

Z Akbari, I Rasooli, MH Ghaini, S Chaudhuri… - International …, 2022 - Elsevier
The complexity of treating Acinetobacter baumannii infections with the newly developed
resistant strains has led researchers to confront this pathogen by developing vaccines. In …

Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence

S Gulati, AH Mattsson, S Schussek, B Zheng… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT A safe and effective vaccine is urgently needed to combat the global threat of
multidrug-resistant (MDR) Neisseria gonorrhoeae. We screened 26 gonococcal proteins …

Hybrid antigens expressing surface loops of BauA from Acinetobacter baumannii are capable of inducing protection against infection

S Chaudhuri, I Rasooli, RH Oskouei… - Frontiers in …, 2022 - frontiersin.org
Acinetobacter baumannii is a human bacterial pathogen of increasing concern in clinical
settings due to the emergence of antibiotic resistant strains and the lack of effective …

Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

MM Soto Perezchica, AL Guerrero Barrera… - Frontiers in Veterinary …, 2023 - frontiersin.org
Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium
that produces porcine pleuropneumonia. This highly contagious disease produces high …

The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments

GB Cole, TJ Bateman, TF Moraes - Journal of Biological Chemistry, 2021 - ASBMB
Gram-negative pathogens are enveloped by an outer membrane that serves as a double-
edged sword: On the one hand, it provides a layer of protection for the bacterium from …

Combination of BauA and OmpA elicit immunoprotection against Acinetobacter baumannii in a murine sepsis model

M Tamehri, I Rasooli, M Pishgahi, A Jahangiri… - Microbial …, 2022 - Elsevier
Aims Acinetobacter baumannii causes severe nosocomial infections and is a difficult-to-treat
pathogen due to the development of multidrug-resistant (MDR) strains. Vaccines and …

Exploitation of two siderophore receptors, BauA and BfnH, for protection against Acinetobacter baumannii infection

Z Aghajani, I Rasooli, SL Mousavi Gargari - Apmis, 2019 - Wiley Online Library
Iron uptake system is expressed in early stages of Acinetobacter baumannii infections under
iron‐restricted conditions. This study is aimed at the evaluation of immuno‐protectivity of …

Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities

KN Delgado, MJ Caimano, IC Orbe, CF Vicente… - PLoS …, 2024 - journals.plos.org
The global resurgence of syphilis has created a potent stimulus for vaccine development. To
identify potentially protective antibodies against Treponema pallidum (TPA), we used …