miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis
CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …
regulating mRNA through its degradation and adjusting protein levels. In recent years …
The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
Systematic review of miRNA as biomarkers in Alzheimer's disease
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood
L Cheng, RA Sharples, BJ Scicluna… - Journal of extracellular …, 2014 - Taylor & Francis
Introduction microRNA (miRNA) are small non-coding RNA species that are transcriptionally
processed in the host cell and released extracellularly into the bloodstream. Normally …
processed in the host cell and released extracellularly into the bloodstream. Normally …
Extracellular vesicles in neurodegenerative disease—pathogenesis to biomarkers
AG Thompson, E Gray, SM Heman-Ackah… - Nature Reviews …, 2016 - nature.com
To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …
markers of diagnosis, disease activity and progression are a research priority. The fact that …
Epigenetics of Alzheimer's disease
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Plasma exosomal miRNAs in persons with and without Alzheimer disease: altered expression and prospects for biomarkers
To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the
expression of microRNAs was measured in a plasma fraction enriched in exosomes by …
expression of microRNAs was measured in a plasma fraction enriched in exosomes by …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
[HTML][HTML] Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss, multiple cognitive abnormalities and intellectual impairments. Currently, there …
memory loss, multiple cognitive abnormalities and intellectual impairments. Currently, there …