Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Background Researchers have documented that child maltreatment is associated with
adverse long-term consequences for mental health, including increased risk for depression …

BackgroundA large literature has long focused on the role of trauma in childhood and risk for
psychological disorders in adulthood. Despite several studies performed, to date, it is not …

Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …

Objective: To perform a meta-analysis including all relevant studies exploring the interaction.
Data Sources: We identified studies published through November 2009 in PubMed. Study …

Children who experience early life toxic stress are at risk of long-term adverse health effects
that may not manifest until adulthood. This article briefly summarizes the findings in recent …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and
influences synaptic efficiency and plasticity. The human BDNF gene consists of 11 exons …