RUNX1 is a critical transcription factor for the emergence of definitive hematopoiesis and the
precise regulation of adult hematopoiesis. Dysregulation of its regulatory network causes …

Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and
play a pivotal role in redox reactions and signal transduction pathways. Contingent upon …

Mitochondrial metabolism plays a pivotal role in various cellular processes and fibrosis.
However, the mechanism underlying mitochondrial metabolic function and liver fibrosis …

The selective autophagic degradation of mitochondria via mitophagy is essential for
preserving mitochondrial homeostasis and, thereby, disease maintenance and progression …

Most patients with advanced cancer develop cachexia, a multifactorial syndrome
characterized by progressive skeletal muscle wasting. Despite its catastrophic impact on …

The disorders known as bone marrow failure syndromes (BMFS) are life-threatening
disorders characterized by absence of one or more hematopoietic lineages in the peripheral …

Inflammation is a key driver of the progression of pre-leukemic myeloid conditions, such as
clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of …

Abstract Dynamin-related protein 1 (DRP1) is a key regulator in the maintenance of
mammalian glucose homeostasis, but the relevant information remains poorly understood …

Although excessive mitochondrial fission is linked to cell activation, its significance in
hepatic stellate cells (HSCs) activation and liver fibrosis is unknown. Here we show that …

Mitochondria are indispensable in maintaining hematopoietic stem cells (HSCs), and
mitochondrial complex II (MCII) has been recognized as a key component of HSCs …