In patients with infection, improving the probability of positive treatment outcomes depends
on optimizing the interactions between the host, pathogen, and drug. In this setting, optimal …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in …

Suppression of resistance in a dense Pseudomonas aeruginosa population has previously
been shown with optimized quinolone exposures. However, the relevance to β-lactams is …

ABSTRACT PPI-0903 is a new cephalosporin with broad-spectrum activity, including beta-
lactam-resistant Streptococcus pneumoniae and Staphylococcus aureus. We used the …

Taking readers from the research laboratory to the bedside, this Second Edition compiles
essential information on the pharmacodynamics of all major classes of the antimicrobial …

Abstract Background Carbapenem-resistant Enterobacterales (CRE) are a public health
concern. Among these isolates, there are reports of isolates that test as cefepime susceptible …

Background Levofloxacin displays in vitro activity against Stenotrophomonas maltophilia
(STM); however, current susceptibility breakpoints are supported by limited data. We …

Background Minocycline displays high susceptibility rates against Stenotrophomonas
maltophilia at the current breakpoint of 4 mg/L. However, no pharmacodynamic data are …