Biocatalytic oxidation reactions: a chemist's perspective

JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

State-of-the-art biocatalysis

JB Pyser, S Chakrabarty, EO Romero… - ACS central …, 2021 - ACS Publications
The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Enzymatic late‐stage modifications: better late than never

E Romero, BS Jones, BN Hogg… - Angewandte Chemie …, 2021 - Wiley Online Library
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Enabling broader adoption of biocatalysis in organic chemistry

EO Romero, AT Saucedo, JR Hernández-Meléndez… - JACS Au, 2023 - ACS Publications
Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

Enzymatic cascade reactions in biosynthesis

CT Walsh, BS Moore - Angewandte Chemie International …, 2019 - Wiley Online Library
Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

Recent Advances on Catalytic Atroposelective Synthesis of Planar‐Chiral Macrocycles

G Yang, J Wang - Angewandte Chemie International Edition, 2024 - Wiley Online Library
Planar‐chiral skeletons widely exist in natural products, bioactive compounds, and other
functional molecules. Although significant progress has been made in the field of …

A family of radical halogenases for the engineering of amino-acid-based products

ME Neugebauer, KH Sumida, JG Pelton… - Nature chemical …, 2019 - nature.com
The integration of synthetic and biological catalysis enables new approaches to the
synthesis of small molecules by combining the high selectivity of enzymes with the reaction …

Broadening the scope of biocatalytic C–C bond formation

LE Zetzsche, ARH Narayan - Nature Reviews Chemistry, 2020 - nature.com
Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …

The transformative power of biocatalysis in convergent synthesis

LE Zetzsche, S Chakrabarty… - Journal of the American …, 2022 - ACS Publications
Achieving convergent synthetic strategies has long been a gold standard in constructing
complex molecular skeletons, allowing for the rapid generation of complexity in …

Review on recent developments in biocatalysts for Friedel–Crafts reactions

V Kumar, WB Turnbull, A Kumar - ACS Catalysis, 2022 - ACS Publications
The Friedel–Crafts (F–C) reaction has been a fundamental pillar of both academic and
industrial synthetic organic chemistry since its discovery in 1873. Its success is based on the …