Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Primary familial brain calcification (PFBC), also known as Fahr's disease, is a rare inherited
disorder characterized by bilateral calcification in the basal ganglia according to …

Infantile myofibromatosis is one of the most prevalent soft tissue tumors of infancy and
childhood. Multifocal nodules with visceral lesions are associated with a poor prognosis. A …

Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by
progressive pericapillary calcifications, has recently been linked to heterozygous mutations …

Primary familial brain calcification (PFBC) is an inherited neurodegenerative disorder mainly
characterized by progressive calcium deposition bilaterally in the brain, accompanied by …

Recently, germline and somatic heterozygous mutations in the platelet-derived growth factor
receptor β (PDGFRB) have been associated with familial infantile myofibromatosis (IM) …

Primary Familial Brain Calcification (PFBC) is a dominantly inherited cerebral microvascular
calcifying disorder with diverse neuropsychiatric expression. Three causative genes have …

Brain calcifications are commonly detected in aged individuals and accompany numerous
brain diseases, but their functional importance is not understood. In cases of primary familial …