Programmable and multifunctional DNA‐based materials for biomedical applications
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
Biological applications of synthetic anion transporters
The use of synthetic ion transporters for alteration of the concentration of ions across cell
membranes has drawn attention from scientists over the last two decades. This ion transport …
membranes has drawn attention from scientists over the last two decades. This ion transport …
Squaramides as bioisosteres in contemporary drug design
KA Agnew-Francis, CM Williams - Chemical Reviews, 2020 - ACS Publications
Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …
Fatty-amine-conjugated cationic bovine serum albumin nanoparticles for target-specific hydrophobic drug delivery
Protein-based nanostructures have reformed nanoscience and nanotechnology on account
of their smaller sizes and greater surface areas, which instigate their interactions with other …
of their smaller sizes and greater surface areas, which instigate their interactions with other …
[HTML][HTML] Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A
M Berney, W Doherty, WT Jauslin, MT Manoj… - Bioorganic & Medicinal …, 2021 - Elsevier
SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink
lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a …
lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a …
Diphenylethylenediamine-based potent anionophores: transmembrane chloride ion transport and apoptosis inducing activities
Synthetic anion transporters have been recognized as one of the potential therapeutic
agents for the treatment of diseases including cystic fibrosis, myotonia, and epilepsy that …
agents for the treatment of diseases including cystic fibrosis, myotonia, and epilepsy that …
Zwitterionic Amino‐Acid‐Derived Polyacrylamides with a Betaine Twist–Synthesis and Characterization
J De Breuck, V Jérôme, R Freitag… - Macromolecular Rapid …, 2024 - Wiley Online Library
Amino‐acid‐derived polyzwitterions and polybetaines (PBs) are two promising alternatives
to non‐ionic polymers, for example, to increase tumor permeability. In this study, amino‐acid …
to non‐ionic polymers, for example, to increase tumor permeability. In this study, amino‐acid …
pH-Regulated anion transport activities of bis (iminourea) derivatives across the cell and vesicle membrane
Recently, synthetic anion transporters have gained considerable attention because of their
ability to disrupt cellular anion homeostasis and promote cell death. Herein, we report the …
ability to disrupt cellular anion homeostasis and promote cell death. Herein, we report the …
Stimuli-responsive transmembrane anion transport by AIE-active fluorescent probes
Anticancer drug resistance implicates multifunctional mechanisms, and hypoxia is one of the
key factors in therapeutic resistance. Hypoxia-specific therapy is considered an extremely …
key factors in therapeutic resistance. Hypoxia-specific therapy is considered an extremely …
Oseltamivir analogs with potent anti-influenza virus activity
S Kumar, S Goicoechea, S Kumar, CM Pearce… - Drug Discovery …, 2020 - Elsevier
Highlights•Despite of vaccines, therapeutics are critically important to keep check on
evolving virulence from mutations.•Oseltamivir remains a single effective oral drug against …
evolving virulence from mutations.•Oseltamivir remains a single effective oral drug against …