Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress

CM Ahmed, HM Johnson, AS Lewin - Frontiers in Immunology, 2024 - frontiersin.org
Several blinding diseases affecting the retina and optic nerve are exacerbated by or caused
by dysregulated inflammation and oxidative stress. These diseases include uveitis, age …

[HTML][HTML] Glaucoma and the ocular renin-angiotensin-aldosterone system: Update on molecular signalling and treatment perspectives

F Buonfiglio, N Pfeiffer, A Gericke - Cellular Signalling, 2024 - Elsevier
Glaucoma, a leading cause of blindness worldwide, encompasses a group of pathological
conditions affecting the optic nerve and is characterized by progressive retinal ganglion cell …

[HTML][HTML] Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4

HJ Hao, YH Li, B Yu, X Liu, Y Zhang… - International Journal of …, 2024 - ncbi.nlm.nih.gov
AIM To explore the therapeutic effect and main molecular mechanisms of acteoside in a
glaucoma model in DBA/2J mice. METHODS Proteomics was used to compare the …

Exploring Ocular Disorders in Parkinson's Disease: A Comprehensive Review and Future Perspectives

M Thacker, KY Wong, L Zhou, J Liu… - Experimental Eye …, 2024 - Elsevier
Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by
predominantly motor symptoms. However, recent research has broadened our …

[HTML][HTML] Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?

J Li, F Buonfiglio, Y Zeng, N Pfeiffer, A Gericke - Antioxidants, 2024 - mdpi.com
Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-
induced damage to lens epithelial cells (LECs). Key factors contributing to cataract formation …

Current Insights on Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and their significance in the pathophysiology of ocular disorders

XY Zhang, C Han, Y Yao, TT Wei - Experimental Eye Research, 2024 - Elsevier
The intricate interaction network necessary for essential physiological functions underscores
the interdependence among eukaryotic cells. Mitochondria-Associated Endoplasmic …

Diabetic Retinopathy: New Treatment Approaches Targeting Redox and Immune Mechanisms

Q Tang, F Buonfiglio, EW Böhm, L Zhang, N Pfeiffer… - Antioxidants, 2024 - mdpi.com
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus,
characterized by irreversible visual impairment resulting from microvascular abnormalities …

Adrenoceptors in the eye–physiological and pathophysiological relevance

Y Ruan, F Buonfiglio, A Gericke - Adrenoceptors, 2023 - Springer
The autonomic nervous system plays a crucial role in the innervation of the eye.
Consequently, it comes as no surprise that catecholamines and their corresponding …

The Effect of Trabecular Aspiration on Intraocular Pressure, Medication and the Need for Further Glaucoma Surgery in Eyes with Pseudoexfoliation Glaucoma

V Prokosch, SB Zwingelberg, DV Efremova… - Diseases, 2024 - mdpi.com
Purpose: To investigate whether trabecular aspiration (TA) has an effective medium-term
intraocular pressure (IOP)-lowering and medication-saving effect in patients with …

Evaluation of Reporting Quality of Glaucoma Randomized Controlled Trial Abstracts: Current Status and Future Perspectives

A Vucinovic, J Bukic, D Rusic, D Leskur… - Life, 2024 - mdpi.com
The aim of this study was to explore adherence to the Consolidated Standards of Reporting
Trials (CONSORT) reporting standards in abstracts of randomized controlled trials on …