MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke
Z Jia, H Li, K Xu, R Li, S Yang, L Chen… - Frontiers in Cellular …, 2024 - frontiersin.org
Ischemic stroke (IS) is the predominant subtype of stroke and a leading contributor to global
mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) is a …
mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) is a …
Shaping cardiac destiny: the role of post-translational modifications on endoplasmic reticulum–mitochondria crosstalk in cardiac remodeling
X Zhang, S Shi, Y Du, R Chai, Z Guo, C Duan… - Frontiers in …, 2024 - frontiersin.org
Cardiac remodeling is a shared pathological change in most cardiovascular diseases.
Encompassing both adaptive physiological responses and decompensated pathological …
Encompassing both adaptive physiological responses and decompensated pathological …
[HTML][HTML] Activating Sig-1R inhibits microvascular permeability by reducing LRRK2 expression in lipopolysaccharide-induced acute lung injury
B Lin, Y Li, Y Yao, B Yu, P Ke, T Wang, W Qiu… - Free Radical Biology …, 2025 - Elsevier
Background Endothelial cells are the first and most damaged target cells during acute lung
injury (ALI). Endothelial dysfunction increases pulmonary microvascular permeability …
injury (ALI). Endothelial dysfunction increases pulmonary microvascular permeability …
Effect of endothelial responses on sepsis-associated organ dysfunction
W Miao, Y Yan, X Xinyu, B Jiawei, M Chengtai… - Chinese Medical …, 2024 - mednexus.org
Sepsis-related organ dysfunction is associated with increased morbidity and mortality.
Previous studies have found that the endothelium plays crucial roles in maintaining the …
Previous studies have found that the endothelium plays crucial roles in maintaining the …
UNVEILING THE PROTECTIVE MECHANISMS OF PUERARIN AGAINST ACUTE LUNG INJURY: A COMPREHENSIVE EXPLORATION OF THE ROLES AND …
W Chen, W Zhang, H Zhang, Y Lai, J Huang, Y Lei… - Shock, 2023 - journals.lww.com
Objectives Puerarin, the principal active constituent extracted from Pueraria, is believed to
confer protection against sepsis-induced lung injury. The study aimed to elucidate the role …
confer protection against sepsis-induced lung injury. The study aimed to elucidate the role …
Pharmacological activation of Sig-1R ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the Akt/GSK-3β/NF-κB pathway
S Cao, L Shi, Y Zhang, Y Shi, X Wang, S Yuan, C Han… - 2024 - researchsquare.com
Diabetic neuropathic pain (DNP) is a common complication of diabetes mellitus (DM) and is
characterized by spontaneous pain and neuroinflammation. The Sigma-1 receptor (Sig-1R) …
characterized by spontaneous pain and neuroinflammation. The Sigma-1 receptor (Sig-1R) …