Hematopoietic stem cells (HSCs) are primarily dormant in a cell-cycle quiescence state to
preserve their self-renewal capacity and long-term maintenance, which is essential for the …

Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs LT) to
trained immunity (TI) in the setting of chronic autoimmune disease. Using a mouse model of …

Hematopoiesis is a highly complex process, regulated by both intrinsic and extrinsic factors.
Often, these two regulatory arms work in tandem to maintain the steady-state condition of …

Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear protein that attaches
negatively charged poly (ADP-ribose)(PAR) to itself and other target proteins. While its …

Abstract Histone H3 lysine 4 (H3K4) methylation is generally recognized as a prominent
marker of gene activation. While Set1/Mll complexes are major methyltransferases that are …

Epigenetics is the heritable phenotypic changes without altering the genotype. Epigenetic
processes are such as histone methylation, acetylation, ubiquitination, sumoylation …

Regulating gene expression through retroviral infection has been widely used in mouse
bone marrow transplantation (BMT) to test the capacity of self-renewal, as well as multi …

Trained immunity (TI) has been speculated to serve as a contributor to autoimmune disease
(AD) pathogenesis via generation of hyper-inflammatory myeloid cells. Using a mouse …

The hematopoietic system is necessary for daily blood generation, and hematopoietic
alterations are common in inflammatory diseases. Due to its role in generating immune cells …