Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to
either inhibit or promote cell death. Altered expression of these proteins occurs commonly in …

A four-pulse version of the pulse double electron–electron resonance (DEER) experiment is
presented, which is designed for the determination of interradical distances on a nanoscopic …

Site-directed spin labeling has emerged as a powerful method for determining the structure
and topography of proteins. The technique has recently been extended to include time …

Despite the rapid pace of new protein structure determination by NMR and crystallographic
means, structural problems remain that are generally inaccessible to these powerful …

The heterotrimeric synaptic soluble N-ethylmaleimide-sensitive factor attachment protein
receptor (SNARE) complex, consisting of the synaptic vesicle-associated membrane protein …

Ten mutants of bacteriorhodopsin, each containing a single cysteine residue regularly
spaced along helix D and facing the lipid bilayer, were derivatized with a nitroxide spin …

Apoptosis, a mechanism for programmed cell death, has key roles in human health and
disease. Many signals for cellular life and death are regulated by the BCL-2 family proteins …

A four‐pulse version of the pulsed double electron electron resonance (DEER) experiment
has been applied to a series of TEMPO diradicals with well‐defined interradical distances …

Perfringolysin O (PFO), a water-soluble monomeric cytolysin secreted by pathogenic
Clostridium perfringens, oligomerizes and forms large pores upon encountering cholesterol …