Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications

W Zhang, R Wang, ZM Sun, X Zhu, Q Zhao… - Chemical Society …, 2020 - pubs.rsc.org
Hydrogels are a unique class of polymeric materials that possess an interconnected porous
network across various length scales from nano-to macroscopic dimensions and exhibit …

Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

Biomolecular phase separation: from molecular driving forces to macroscopic properties

GL Dignon, RB Best, J Mittal - Annual review of physical …, 2020 - annualreviews.org
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

LASSI: A lattice model for simulating phase transitions of multivalent proteins

JM Choi, F Dar, RV Pappu - PLoS computational biology, 2019 - journals.plos.org
Many biomolecular condensates form via spontaneous phase transitions that are driven by
multivalent proteins. These molecules are biological instantiations of associative polymers …

Polyelectrolyte complex coacervation across a broad range of charge densities

AE Neitzel, YN Fang, B Yu, AM Rumyantsev… - …, 2021 - ACS Publications
Polyelectrolyte complex coacervates of homologous (co) polyelectrolytes with a near-ideally
random distribution of a charged and neutral ethylene oxide comonomer were synthesized …

100th anniversary of macromolecular science viewpoint: Opportunities in the physics of sequence-defined polymers

SL Perry, CE Sing - ACS Macro Letters, 2020 - ACS Publications
Polymer science has been driven by ever-increasing molecular complexity, as polymer
synthesis expands an already-vast palette of chemical and architectural parameter space …

Protein encapsulation using complex coacervates: what nature has to teach us

WC Blocher McTigue, SL Perry - Small, 2020 - Wiley Online Library
Protein encapsulation is a growing area of interest, particularly in the fields of food science
and medicine. The sequestration of protein cargoes is achieved using a variety of methods …

Tie-line analysis reveals interactions driving heteromolecular condensate formation

D Qian, TJ Welsh, NA Erkamp, S Qamar, J Nixon-Abell… - Physical Review X, 2022 - APS
Phase separation of biomolecules gives rise to membraneless organelles that contribute to
the spatiotemporal organization of the cell. In most cases, such biomolecular condensates …

Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications

H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …