Biogeochemistry of Actinides: Recent Progress and Perspective

GJP Deblonde - ACS Environmental Au, 2024 - ACS Publications
Actinides are elements that are often feared because of their radioactive nature and
potentially devastating consequences to humans and the environment if not managed …

Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions

JA Mattocks, JA Cotruvo, GJP Deblonde - Chemical Science, 2022 - pubs.rsc.org
Developing chelators that combine high affinity and selectivity for lanthanides and/or
actinides is paramount for numerous industries, including rare earths mining, nuclear waste …

Equilibrium thermodynamics of macropa complexes with selected metal isotopes of radiopharmaceutical interest

MK Blei, L Waurick, F Reissig, K Kopka… - Inorganic …, 2023 - ACS Publications
To pursue the design of in vivo stable chelating systems for radiometals, a concise and
straightforward method toolbox was developed combining NMR, isothermal titration …

Characterization of americium and curium complexes with the protein lanmodulin: a potential macromolecular mechanism for actinide mobility in the environment

GJP Deblonde, JA Mattocks, H Wang… - Journal of the …, 2021 - ACS Publications
Anthropogenic radionuclides, including long-lived heavy actinides such as americium and
curium, represent the primary long-term challenge for management of nuclear waste. The …

Americium preferred: lanmodulin, a natural lanthanide-binding protein favors an actinide over lanthanides

H Singer, B Drobot, C Zeymer, R Steudtner… - Chemical …, 2021 - pubs.rsc.org
The separation and recycling of lanthanides is an active area of research with a growing
demand that calls for more environmentally friendly lanthanide sources. Likewise, the …

Lanmodulin peptides–unravelling the binding of the EF-Hand loop sequences stripped from the structural corset

SM Gutenthaler, S Tsushima, R Steudtner… - Inorganic Chemistry …, 2022 - pubs.rsc.org
Lanmodulin (LanM), a naturally lanthanide (Ln)-binding protein with a remarkable selectivity
for Lns over Ca (II) and affinities in the picomolar range, is an attractive target to address …

Impact of a Biological Chelator, Lanmodulin, on Minor Actinide Aqueous Speciation and Transport in the Environment

GJP Deblonde, K Morrison, JA Mattocks… - Environmental …, 2023 - ACS Publications
Minor actinides are major contributors to the long-term radiotoxicity of nuclear fuels and
other radioactive wastes. In this context, understanding their interactions with natural …

Interaction analyses of SARS-CoV-2 spike protein based on fragment molecular orbital calculations

K Akisawa, R Hatada, K Okuwaki, Y Mochizuki… - RSC …, 2021 - pubs.rsc.org
At the stage of SARS-CoV-2 infection in human cells, the spike protein consisting of three
chains, A, B, and C, with a total of 3300 residues plays a key role, and thus its structural …

Not just a background: pH buffers do interact with lanthanide ions—a Europium (III) case study

P Mandal, J Kretzschmar, B Drobot - JBIC Journal of Biological Inorganic …, 2022 - Springer
The interaction between Eu (III) ion and different pH buffers, popular in biology and
biochemistry, viz. HEPES, PIPES, MES, MOPS, and TRIS, has been studied by solution …

Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with …

C Handa, Y Yamazaki, S Yonekubo, N Furuya… - The Journal of Steroid …, 2022 - Elsevier
Estrogen receptors (ERs) are ligand-activated transcription factors, with two subtypes ERα
and ERβ. The endogenous ligand of ERs is the common 17β-estradiol, and the ligand …