This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

During the last decade, capillary electrophoresis (CE) of DNA has undergone rapid
development. This improvement was especially important for DNA sequencing, where CE …

The free‐draining properties of DNA normally make it impossible to separate nucleic acids
by free‐flow electrophoresis. However, little is known, either theoretically or experimentally …

▪ Abstract The Human Genome Project and other major genomic sequencing projects have
pushed the development of sequencing technology. In the past six years alone, instrument …

Abstract Theory and numerical simulations play a major role in the development of improved
and novel separation methods. In some cases, computer simulations predict counterintuitive …

We report here a technology to carry out separations of a wide range of DNA fragments with
high speed and high resolution. The approach uses a nanoparticle medium, core-shell type …

Advances in microchannel electrophoretic separation systems for DNA analyses have had
important impacts on biological and biomedical sciences, as exemplified by the successes …

DNA is a free‐draining polymer. This subtle but “unfortunate” property of highly charged
polyelectrolytes makes it impossible to separate nucleic acids by free‐flow electrophoresis …

Although electrophoresis is one of the basic methods of the modern molecular biology
laboratory, new ideas are being suggested at an accelerated rate, in large part because of …

Early molecular methods in clinical genetic diagnostics were frequently regarded as
unambiguous and definitive. The power of modern molecular biology was seen as sufficient …