microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

ABSTRACT microRNAs (miRNAs) and DNA methylation are the 2 epigenetic modifications
that have emerged in recent years as the most critical players in the regulation of gene …

Ovarian cancer is a disease with a poor prognosis and little progress has been made to
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …

Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …

Purpose: To investigate SGI-110 as a “chemosensitizer” in ovarian cancer and to assess its
effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes …

Purpose: Epigenetic host cell changes involved in cervical cancer development following a
persistent high-risk human papillomavirus (hrHPV) infection, provide promising markers for …

The cancer stem cell hypothesis has been put forward as a paradigm to describe varying
levels of aggressiveness in heterogeneous tumors. Specifically, many subpopulations have …

Next‐generation sequencing (NGS) technologies have greatly impacted on every field of
molecular research mainly because they reduce costs and increase throughput of DNA …

Zic family member ZIC4 is a transcription factor that has been shown to be silenced in
several cancers. However, understanding the regulation and function of ZIC4 in pediatric …

Epigenetics refers to the collection of heritable features that modulate the genome–
environment interaction without being encoded in the actual DNA sequence. While being …