Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

Members of the APOBEC family of cytidine deaminases show antiviral activities in
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA
cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this …

HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections
resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case …

Background: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern
of localised hypermutation. We assessed the cellular phenotypes associated with high-level …

Background Although APOBEC-mutational signature is found in tumor tissues of multiple
cancers, how a common germline APOBEC3A/B deletion affects the mutational signature …

Human cancers results in large part from the accumulation of multiple mutations. The
progression of premalignant cells is an evolutionary process in which mutations provide the …

Bats have attracted attention in recent years as important reservoirs of viruses deadly to
humans and other mammals. These infections are typically nonpathogenic in bats raising …

The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple
cancer types. These APOBEC-signature mutations are non-uniformly distributed across …