Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …

The ability to sense and respond to osmotic fluctuations is critical for the maintenance of
cellular integrity. We used gene co-essentiality analysis to identify an unappreciated …

Chloride deregulation and GABA depolarization in MTOR-related malformations of cortical
development Page 1 https://doi.org/10.1093/brain/awae262 BRAIN 2024: 00; 1–15 | 1 Chloride …

Background Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+] …

Physiological roles of Cl−, a major anion in the body, are not well known compared with
those of cations. This review article introduces:(1) roles of Cl− in bodily and cellular …

The mammalian target of rapamycin (mTOR) signaling pathway is crucial in maintaining cell
growth and metabolism. The mTOR protein kinase constitutes the catalytic subunit of two …

This review highlights the molecular basis of salt sensitivity in hypertension, with a focus on
the regulation of sodium transport in the distal nephron. Sodium reabsorption in this region …

BACKGROUND: Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+] …

Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six
known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all …