Rotavirus research: 2014–2020

S Caddy, G Papa, A Borodavka, U Desselberger - Virus research, 2021 - Elsevier
Rotaviruses are major causes of acute gastroenteritis in infants and young children
worldwide and also cause disease in the young of many other mammalian and of avian …

[PDF][PDF] On the stability of sequences inserted into viral genomes

A Willemsen, MP Zwart - Virus Evolution, 2019 - academic.oup.com
Viruses are widely used as vectors for heterologous gene expression in cultured cells or
natural hosts, and therefore a large number of viruses with exogenous sequences inserted …

Mucosal and systemic neutralizing antibodies to norovirus induced in infant mice orally inoculated with recombinant rotaviruses

T Kawagishi, L Sánchez-Tacuba… - Proceedings of the …, 2023 - National Acad Sciences
Rotaviruses (RVs) preferentially replicate in the small intestine and frequently cause severe
diarrheal disease, and the following enteric infection generally induces variable levels of …

Type III and not type I interferons efficiently prevent the spread of rotavirus in human intestinal epithelial cells

P Doldan, J Dai, C Metz-Zumaran, JT Patton… - Journal of …, 2022 - Am Soc Microbiol
Rotavirus infects intestinal epithelial cells and is the leading cause of gastroenteritis in
infants worldwide. Upon viral infection, intestinal cells produce type I and type III interferons …

An optimized reverse genetics system suitable for efficient recovery of simian, human, and murine-like rotaviruses

L Sánchez-Tacuba, N Feng, NJ Meade… - Journal of …, 2020 - Am Soc Microbiol
An entirely plasmid-based reverse genetics (RG) system was recently developed for
rotavirus (RV), opening new avenues for in-depth molecular dissection of RV biology …

Flexibility of the rotavirus NSP2 C-terminal region supports factory formation via liquid-liquid phase separation

SL Nichols, EM Nilsson, H Brown-Harding… - Journal of …, 2023 - Am Soc Microbiol
Many viruses sequester the materials needed for their replication into discrete subcellular
factories. For rotaviruses (RVs), these factories are called viroplasms, and they are formed in …

Using species a rotavirus reverse genetics to engineer chimeric viruses expressing SARS-CoV-2 spike epitopes

O Diebold, V Gonzalez, L Venditti, C Sharp… - Journal of …, 2022 - Am Soc Microbiol
Species A rotavirus (RVA) vaccines based on live attenuated viruses are used worldwide in
humans. The recent establishment of a reverse genetics system for rotoviruses (RVs) has …

Recent advances in rotavirus reverse genetics and its utilization in basic research and vaccine development

T Uprety, D Wang, F Li - Archives of virology, 2021 - Springer
Rotaviruses are segmented double-stranded RNA viruses with a high frequency of gene
reassortment, and they are a leading cause of global diarrheal deaths in children less than 5 …

Generation of recombinant rotaviruses expressing human norovirus capsid proteins

AA Philip, JT Patton - Journal of Virology, 2022 - Am Soc Microbiol
Rotavirus, a segmented double-stranded RNA virus of the Reoviridae family, is a primary
cause of acute gastroenteritis in young children. In countries where rotavirus vaccines are …

Production of OSU G5P [7] Porcine Rotavirus Expressing a Fluorescent Reporter via Reverse Genetics

AJ Snyder, CA Agbemabiese, JT Patton - Viruses, 2024 - mdpi.com
Rotaviruses are a significant cause of severe, potentially life-threatening gastroenteritis in
infants and the young of many economically important animals. Although vaccines against …