Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcoma is the most common primary malignancy of bone in children and young
adults. This tumor has a very heterogeneous genetic profile and lacks any consistent …

Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class
of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to …

Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment
strategies target the primary tumour rather than metastases and have a limited efficacy in the …

The ability of osteosarcoma cells to form lung metastases has been inversely correlated to
cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to circumvent …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Osteosarcoma is the most common primary malignancy of bone and patients often develop
pulmonary metastases. In order to investigate the pathogenesis of human osteosarcoma …

Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most
common primary bone tumor among children. Despite the significant advances made in the …

Introduction: The standard treatment for osteosarcoma requires both macroscopic surgical
wide resection and postoperative multi-drug chemotherapy in neoadjuvant and adjuvant …

Osteosarcoma is a primary malignancy of bone with a high tendency to metastasize.
Although it can occur at any age, osteosarcoma has a peak incidence in the second decade …