High-valent non-heme iron–oxo intermediates have been proposed for decades as the key
intermediates in numerous biological oxidation reactions. In the past three years, the first …

Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an
extended enzyme family that catalyze a wide range of oxidation reactions. The largest …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

The past 15 years have seen an explosive growth in the number of enzymatic reactions
found to proceed by mechanisms involving free radicals as intermediates. One of us learned …

Isopenicillin N synthase (IPNS) catalyzes a key step in the biosynthesis of the important β-
lactam antibiotics penicillins and cephalosporins. Density-functional calculations with the …

The β‐lactam classes of antibacterials are preeminent in the treatment of bacterial infection
due to their unparalleled clinical efficacy and clinical safety. Following the discovery of the …

In metalloproteins, the protein environment modulates metal properties to achieve the
required goal, which can be protein stabilization or function. The analysis of metal sites at …

Abstract β‐Lactam antibiotics have been used for many years to treat bacterial infections.
However the effective treatment of an increasing range of microbial infections is threatened …

Isopenicillin N synthase (IPNS) is a nonheme iron oxidase that catalyzes the central step in
the biosynthesis of β-lactam antibiotics: oxidative cyclization of the linear tripeptide δ-l-α …

We have developed a database search tool to identify metal sites having structural similarity
to a query metal site structure within the MetalPDB database of minimal functional sites …