Circadian molecular clock disruption in chronic pulmonary diseases
The circadian clock is the biochemical oscillator with a near 24-h period that is responsible
for generating the circadian rhythms in peripheral organs including the lung. Mounting …
for generating the circadian rhythms in peripheral organs including the lung. Mounting …
Circadian molecular clock in lung pathophysiology
IK Sundar, H Yao, MT Sellix… - American Journal of …, 2015 - journals.physiology.org
Disrupted daily or circadian rhythms of lung function and inflammatory responses are
common features of chronic airway diseases. At the molecular level these circadian rhythms …
common features of chronic airway diseases. At the molecular level these circadian rhythms …
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Breast cancer is the most common type of cancer worldwide and one of the major causes of
cancer death in women. Epidemiological studies have established a link between night-shift …
cancer death in women. Epidemiological studies have established a link between night-shift …
[HTML][HTML] Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway
JW Hwang, IK Sundar, H Yao, MT Sellix… - The FASEB …, 2014 - ncbi.nlm.nih.gov
Patients with obstructive lung diseases display abnormal circadian rhythms in lung function.
We determined the mechanism whereby environmental tobacco/cigarette smoke (CS) …
We determined the mechanism whereby environmental tobacco/cigarette smoke (CS) …
The genomic basis of temporal niche evolution in a diurnal rodent
R Richardson, CY Feigin, B Bano-Otalora, MR Johnson… - Current Biology, 2023 - cell.com
Patterns of diel activity—how animals allocate their activity throughout the 24-h daily cycle—
play key roles in shaping the internal physiology of an animal and its relationship with the …
play key roles in shaping the internal physiology of an animal and its relationship with the …
Machine learning helps identify CHRONO as a circadian clock component
Over the last decades, researchers have characterized a set of “clock genes” that drive daily
rhythms in physiology and behavior. This arduous work has yielded results with far-reaching …
rhythms in physiology and behavior. This arduous work has yielded results with far-reaching …
[HTML][HTML] Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity
In peripheral tissues circadian gene expression can be driven either by local oscillators or
by cyclic systemic cues controlled by the master clock in the brain's suprachiasmatic …
by cyclic systemic cues controlled by the master clock in the brain's suprachiasmatic …
The circadian clock and asthma
It is characteristic of asthma that symptoms worsen overnight, particularly in the early hours
of the morning. Nocturnal symptoms in asthma are common and are an important indicator …
of the morning. Nocturnal symptoms in asthma are common and are an important indicator …
Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
F Oesch, E Fabian, R Landsiedel - Archives of toxicology, 2019 - Springer
The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues
Background Many have assumed that the primary function of sleep is for the brain. We
evaluated the molecular consequences of sleep and sleep deprivation outside the brain, in …
evaluated the molecular consequences of sleep and sleep deprivation outside the brain, in …