Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Ferroptosis is a regulated form of necrotic cell death caused by iron-dependent
accumulation of oxidized phospholipids in cellular membranes, culminating in plasma …

The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

The accumulation of lipid hydroperoxides (LOOHs) has long been associated with
numerous pathologies and has more recently been shown to drive a specific type of cell …