Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

The past three decades have witnessed remarkable advances in our ability to target specific
elements of the immune and inflammatory response, fuelled by advances in both …

Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the
serum of thousands of donors and were initially used as an IgG replacement therapy in …

Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from
several thousand healthy donors. It is widely used in the immunotherapy of a large number …

Adeno-associated viral (AAV) vectors have emerged as the leading gene delivery platform
for gene therapy and vaccination. Three AAV-based gene therapy drugs, Glybera …

Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …

Tumor necrosis factor inhibitors (TNFi) have significantly improved treatment outcome of
rheumatic diseases since their incorporation into treatment protocols two decades ago …

Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

OBJECTIVES: Infliximab (IFX) is successfully used in the treatment of inflammatory bowel
diseases but some patients generate antibodies to IFX (ATI) jeopardizing the …