Sharmila Dorbala, MD, MPH, FASNC, Chair*; Yukio Ando, MD, PhD†; Sabahat Bokhari,
MD‡; Angela Dispenzieri, MD § ; Rodney H. Falk, MD*; Victor A. Ferrari, MD∥; Marianna …

Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly diagnosed owing to the
emergence of noninvasive imaging and improved awareness. Clinical penetrance of …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the
deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the …

Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the
deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the …

Background Older patients with severe aortic stenosis (AS) are increasingly identified as
having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse …

Aims Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic
stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients …

The amyloidoses are a group of protein-folding disorders in which≥ 1 organ is infiltrated by
proteinaceous deposits known as amyloid. The deposits are derived from 1 of several …

The prevalence of calcific aortic stenosis (AS) and of cardiac amyloidosis (CA) increases
with age, and their association is not uncommon in the elderly. The identification of CA is …

Aims Wild-type transthyretin amyloidosis (ATTRwt) is mostly considered a disease
predominantly of elderly male, characterized by concentric LV hypertrophy, preserved LVEF …