The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

Conspectus The total synthesis of structurally complex natural products has challenged and
inspired generations of chemists and remains an exciting area of active research. Despite …

The continuing expansion of protein and genome sequence databases is an opportunity to
identify novel enzymes with biotechnological applications. Whether applied to enzymology …

Due to their inherent ring strain and electrophilicity, epoxides are highly attractive building
blocks for fundamental organic reactions. However, controlling the regioselectivity of …

Amine dehydrogenases (AmDHs) catalyze the enzymatic reduction of ketones to amines,
serving as a suitable biocatalytic route for amine synthesis. A limited number of …

Abstract C (sp3)− H oxyfunctionalization, the insertion of an O‐atom into C (sp3)− H bonds,
streamlines the synthesis of complex molecules from easily accessible precursors and …

Activity-based protein profiling (ABPP) has emerged as a versatile biochemical method for
studying enzyme activity under various physiological conditions, with applications so far …

Many enzymes possess high catalytic efficiency and selectivity that far surpass classical
organic or organometallic catalysts. However, the initial starting enzyme for a given …

Descriptors play a pivotal role in enzyme design for the greener synthesis of biochemicals,
as they could characterize enzymes and chemicals from the physicochemical and …