In the past few decades, extensive studies have been performed and have shown the
causative role of ironmediated lipid peroxidation (LPO) in human diseases and in the …

Significance: Mitochondria are fundamental to the life and proper functioning of cells. These
organelles play a key role in energy production, in maintaining homeostatic levels of second …

Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for
tryptophan degradation and an antagonist of both N-methyl-d-aspartate (NMDA) and alpha …

High altitude exposure results in decreased partial pressure of oxygen and an increased
formation of reactive oxygen and nitrogen species (RONS), which causes oxidative damage …

Lipid peroxidation by reactive oxygen species (ROS) is known to be involved in the
damaging mechanism of several acute and chronic brain disorders. The most prominent and …

Mitochondrial dysfunction and oxidative stress are two interdependent and reinforcing
damage mechanisms that play a central role in brain aging. Oxidative stress initiated and …

Cognitive and neuropsychological functions have been impaired at high altitude and the
effects depend on altitude and duration of stay. However, the neurobiological mechanism of …

The autoxidation and monoamine oxidase (MAO)-mediated metabolism of dopamine (3-
hydroxytyramine; DA) cause a continuous production of hydroxyl radical (OH), which is …

Amla (Phyllanthus emblica L.), apart from its food value, can be used as a gastroprotective
agent in non steroidal anti‐inflammatory drug (NSAID)‐induced gastropathy. It has been …

The elucidation of the intriguing relationship between oxidative stress and Alzheimer's
disease is crucial to understand the pathogenesis of the disease as also to design a suitable …