Radical S-adenosyl-l-methionine (SAM) enzymes belong to a family of catalysts whose
number of annotated sequences is still growing. Upon the one-electron reduction of a …

A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …

Arsinothricin is a potent antibiotic secreted by soil bacteria. The biosynthesis of arsinothricin
was proposed to involve a C–As bond formation between trivalent As and the 3-amino-3 …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Radical S-adenosyl-l-methionine (SAM) enzymes comprise a vast superfamily catalyzing
diverse reactions essential to all life through homolytic SAM cleavage to liberate the highly …

Diphthamide, a post-translationally modified histidine residue of eukaryotic TRANSLATION
ELONGATION FACTOR2 (eEF2), is the human host cell-sensitizing target of diphtheria toxin …

The autosomal-recessive diphthamide deficiency syndrome presents as intellectual
disability with developmental abnormalities, seizures, craniofacial and additional …

Synthetic [Fe4S4] clusters with Fe–R groups (R= alkyl/benzyl) are shown to release organic
radicals on an [Fe4S4] 3+–R/[Fe4S4] 2+ redox couple, the same that has been proposed for …

Although alkyl complexes of [Fe4S4] clusters have been invoked as intermediates in a
number of enzymatic reactions, obtaining a detailed understanding of their reactivity patterns …

Covering: 1977 to present Arsenic is widely distributed throughout terrestrial and aquatic
environments, mainly in highly toxic inorganic forms. To adapt to environmental inorganic …