An overview of repurposed drugs for potential COVID-19 treatment
K Govender, A Chuturgoon - Antibiotics, 2022 - mdpi.com
The COVID-19 pandemic caused by SARS-CoV-2 has placed severe constraints on
healthcare systems around the globe. The SARS-CoV-2 virus has caused upheaval in the …
healthcare systems around the globe. The SARS-CoV-2 virus has caused upheaval in the …
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
LV Yevsieieva, KO Lohachova, A Kyrychenko… - RSC …, 2023 - pubs.rsc.org
The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …
H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
Structure-based design of SARS-CoV-2 papain-like protease inhibitors
The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site
Y Shiraishi, I Shimada - Journal of the American Chemical Society, 2023 - ACS Publications
Papain-like protease (PLpro) from severe acute respiratory syndrome Coronavirus 2 (SARS-
CoV-2) is a prime target for the development of antivirals for Coronavirus disease 2019 …
CoV-2) is a prime target for the development of antivirals for Coronavirus disease 2019 …
Bacterial ubiquitin ligases hijack the host deubiquitinase OTUB1 to inhibit MTORC1 signaling and promote autophagy
K Ma, W Xian, H Liu, R Shu, J Ge, ZQ Luo, X Liu, J Qiu - Autophagy, 2024 - Taylor & Francis
Many bacterial pathogens have evolved effective strategies to interfere with the
ubiquitination network to evade clearance by the innate immune system. Here, we report …
ubiquitination network to evade clearance by the innate immune system. Here, we report …
Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
M van Huizen, JR Bloeme-ter Horst… - PLoS …, 2024 - journals.plos.org
The coronavirus papain-like protease (PLpro) is crucial for viral replicase polyprotein
processing. Additionally, PLpro can subvert host defense mechanisms by its …
processing. Additionally, PLpro can subvert host defense mechanisms by its …
Repurposing 1, 2, 4-oxadiazoles as SARS-CoV-2 PLpro inhibitors and investigation of their possible viral entry blockade potential
MS Ayoup, MM ElShafey, H Abdel-Hamid… - European Journal of …, 2023 - Elsevier
Although vaccines are obviously mitigating the COVID-19 pandemic diffusion, efficient
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …
Myocarditis: causes, mechanisms, and evolving therapies
T Kyaw, G Drummond, A Bobik… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Myocarditis is a severe lymphocyte-mediated inflammatory disorder of the heart,
mostly caused by viruses and immune checkpoint inhibitors (ICIs). Recently, myocarditis as …
mostly caused by viruses and immune checkpoint inhibitors (ICIs). Recently, myocarditis as …
SARS-CoV-2 and UPS with potentials for therapeutic interventions
J Ferdoush, RA Kadir, SS Kaplanoglu, M Osborn - Gene, 2024 - Elsevier
The Ubiquitin proteasome system (UPS), an essential eukaryotic/host/cellular post-
translational modification (PTM), plays a critical role in the regulation of diverse cellular …
translational modification (PTM), plays a critical role in the regulation of diverse cellular …