Endogenous retroviruses in the origins and treatment of cancer

N Jansz, GJ Faulkner - Genome biology, 2021 - Springer
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.

R Löwer, J Löwer, R Kurth - Proceedings of the National …, 1996 - National Acad Sciences
Human endogenous retroviruses (HERVs) are very likely footprints of ancient germ-cell
infections. HERV sequences encompass about 1% of the human genome. HERVs have …

The evolution, distribution and diversity of endogenous retroviruses

R Gifford, M Tristem - Virus genes, 2003 - Springer
The retroviral capacity for integration into the host genome can give rise to endogenous
retroviruses (ERVs): retroviral sequences that are transmitted vertically as part of the host …

The evolutionary dynamics of human endogenous retroviral families

N Bannert, R Kurth - Annu. Rev. Genomics Hum. Genet., 2006 - annualreviews.org
The capacity to integrate into the chromosomal DNA of germ-line cells has endowed
retroviruses with the potential to be vertically transmitted from generation to generation and …

Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database

M Tristem - Journal of virology, 2000 - Am Soc Microbiol
Human endogenous retroviruses (HERVs) were first identified almost 20 years ago, and
since then numerous families have been described. It has, however, been difficult to obtain a …

Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome

M Ono, T Yasunaga, T Miyata, H Ushikubo - Journal of virology, 1986 - Am Soc Microbiol
We determined the complete nucleotide sequence of the human endogenous retrovirus
genome HERV-K10 isolated as the sequence homologous to the Syrian hamster …

Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D

M Ono, M Kawakami, H Ushikubo - Journal of virology, 1987 - Am Soc Microbiol
Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse
mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines …

Constructing primate phylogenies from ancient retrovirus sequences

WE Johnson, JM Coffin - Proceedings of the National …, 1999 - National Acad Sciences
The genomes of modern humans are riddled with thousands of endogenous retroviruses
(HERVs), the proviral remnants of ancient viral infections of the primate lineage. Most …

Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease

HB Urnovitz, WH Murphy - Clinical microbiology reviews, 1996 - Am Soc Microbiol
Retroviral diagnostics have become standard in human laboratory medicine. While current
emphasis is placed on the human exogenous viruses (human immunodeficiency virus and …

Reverse transcription in the eukaryotic genome: retroviruses, pararetroviruses, retrotransposons, and retrotranscripts.

HM Temin - Molecular biology and evolution, 1985 - academic.oup.com
Recent studies indicate that greater than 10% of the human and mouse genome appears to
consist of integrated DNA copies of RNA molecules. These sequences include retroviruses …