Coronavirus disease 2019 (COVID-19) is a viral infection with the novel severe acute
respiratory distress syndrome corona virus 2 (SARS-CoV-2). Until now, more than 670 …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Elevated pro-inflammatory biomarkers and cytokines are associated with morbidity and
mortality in heart failure (HF). Preclinical and clinical studies have shown multiple …

Cardiovascular (CV) disease and heart failure (HF) are the leading cause of mortality in type
2 diabetes (T2DM), a metabolic disease which represents a fast-growing health challenge …

Cardiovascular disease (CVD) constitutes a real pandemic of the 21st century. According to
data from the Centers for Disease Control and Prevention, one person dies every 34 min …

Background: Several strategies based on immune checkpoint inhibitors (ICIs) have been
developed for cancer therapy, opening to advantages in cancer outcomes. However, several …

Virtually all types of cardiovascular diseases are associated with pathological activation of
the innate immune system. The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD) …

Aging is an important risk factor for the development of heart failure (HF) and half of patients
with HF have preserved ejection fraction (HFpEF) which is more common in elderly women …

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure
commonly ensues in patients with severe obesity and the obese phenotype of preserved …

Epicardial adipose tissue (EAT) is an endocrine and paracrine organ constituted by a layer
of adipose tissue directly located between the myocardium and visceral pericardium. Under …