The transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling
pathways play a pivotal role in bone development and skeletal health. More than 30 different …

The ADAMTS (ad isintegrin-like and metalloproteinase domain with thrombospondin-type 1
motifs) protein superfamily includes 19 secreted metalloproteases and 7 secreted ADAMTS …

The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7
ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant …

Autosomal recessive congenital ichthyosis (ARCI) is a rare genetic disorder of the skin
characterized by abnormal desquamation over the whole body. In this study we report four …

Knowledge on the genetic epidemiology of disorders in the dog population has implications
for both veterinary medicine and sustainable breeding. Limited data on frequencies of …

The domestic dog genome-shaped by domestication, adaptation to human-dominated
environments and artificial selection-encodes tremendous phenotypic diversity. Recent …

Autosomal recessive and autosomal dominant forms of Weill-Marchesani syndrome, an
inherited connective tissue disorder, are caused by mutations in ADAMTS10 (encoding a …

One quadrillion synapses are laid in the first two years of postnatal construction of the
human brain, which are then pruned until age 10 to 500 trillion synapses composing the …

A recessive, adult-onset neuronal ceroid-lipofuscinosis (NCL) occurs in Tibetan terriers. A
genome-wide association study restricted this NCL locus to a 1.3 Mb region of canine …

A rose may be a rose by any other name, but when you call a dog a poodle it becomes a
very different animal than if you call it a bulldog. Both the poodle and the bulldog are …