Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is one of the key
factors regulating glucose and lipid energy metabolism, and is the core focus of current …

BACKGROUND Hepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver
disease (NAFLD). Improvements in hepatic fat by dietary sugar reduction may be mediated …

Metabolic dysfunction-associated fatty liver disease (MAFLD) is an increasingly prevalent
fellow traveller with the insulin resistance that underlies type 2 diabetes mellitus. However …

Non-alcoholic fatty liver disease (NAFLD) represents a predominant hepatopathy that is
rapidly becoming the most common cause of hepatocellular carcinoma worldwide. The …

Background Triglyceride-rich lipoproteins particles (TRLP) and low density lipoprotein
particles (LDLP) vary in size. Their association with β-cell function is not well described. We …

Background The discovery of insulin in 1921 and its near-immediate clinical use initiated a
century of innovation. Advances extended across a broad front, from the stabilization of …

NAFLD, or metabolic dysfunction–associated steatotic liver disease, has increased in
prevalence hand in hand with the rise in obesity and increased free sugars in the food …

Background & Aims Hepatic energy metabolism is a dynamic process modulated by multiple
stimuli. In nonalcoholic fatty liver disease (NAFLD), human studies typically focus on the …

Adipose tissue is the site of long-term energy storage. During the fasting state, exercise, and
cold exposure, the white adipose tissue mobilizes energy for peripheral tissues through …