During wound healing and surgical implantation, the body establishes a delicate balance
between immune activation to fight off infection and clear debris and immune tolerance to …

Excessive accumulation of intermuscular adipose tissue (IMAT) is a common pathological
feature in various metabolic and health conditions and can cause muscle atrophy, reduced …

Skeletal muscle is composed of a variety of tissue and non-tissue resident cells that
participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system …

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or
through self-renewal. While the presence of a nurturing niche is likely crucial to support the …

Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal
muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle …

Spinal muscular atrophy (SMA) is one of the most frequent causes of death in childhood.
The disease's molecular basis is deletion or mutations in the SMN1 gene, which produces …

Skeletal muscle relies on its inherent self-repair ability to withstand continuous mechanical
damage. Myofiber-intrinsic processes facilitate the repair of damage to sarcolemma and …

Hyper-activation of the canonical Wnt signaling pathway drives small intestine and colon
tumors. As the major Wnt pathway effector in healthy intestines, TCF7L2 is a suspected …

Muscle regeneration is a highly orchestrated process in which multiple tissue-resident and
infiltrating cells actively participate to ensure optimal repair and functional recovery. More …