Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …

Chimeric antigen receptor (CAR) T cell therapy has made tremendous strides in the arena of
hematological malignancies with approved therapies in certain leukemias, lymphomas, and …

Simple Summary Antibody-Drug Conjugates (ADCs) provide effective anti-cancer
treatments. ADC development requires the identification of appropriate tumour-associated …

Importance As the third most frequently mutated gene in cancers, the association
betweenMUC16mutation and response to immune checkpoint inhibitors (ICIs) in solid …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …

Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface
tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor …

As one of the most common gynecologic malignant tumors, ovarian cancer is usually
diagnosed at an advanced and incurable stage because of its early asymptomatic onset …

The fallopian tubes play key roles in processes from pregnancy to ovarian cancer where
three-dimensional (3D) cellular and extracellular interactions are important to their …

Improved outcomes for many types of cancer achieved during recent years is due, among
other factors, to the earlier detection of tumours and the greater availability of screening …