Background RBP-6000, referred to as BUP-XR (extended-release buprenorphine), is a
subcutaneously injected, monthly buprenorphine treatment for opioid use disorder. BUP-XR …

Background Hyperkalemia (serum potassium level,> 5.0 mmol per liter) is associated with
increased mortality among patients with heart failure, chronic kidney disease, or diabetes …

Background Dulaglutide and liraglutide, both glucagon-like peptide-1 (GLP-1) receptor
agonists, improve glycaemic control and reduce weight in patients with type 2 diabetes. In a …

The objective of this paper is to give an overview of a relatively new area of multiplicity
research that deals with the analysis of hierarchically ordered multiple objectives. Testing …

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical
industry, academia, and regulatory agencies, this volume explores the rapidly growing area …

Many authors have proposed different approaches to combine multiple endpoints in a
univariate outcome measure in the literature. In case of binary or time‐to‐event variables …

PURPOSE Tamoxifen is widely prescribed as adjuvant therapy in patients with early-stage
breast cancer. It has been postulated that concentrations of endoxifen, the active metabolite …

Abstract Background Hot flashes (HFs) negatively affect quality of life among
perimenopausal and postmenopausal women. This study investigated the efficacy of …

Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology,
Second Edition explores statistics used in day-to-day clinical pharmacology work. The book …

This study aimed to test the efficacy of Tai Chi for treating chronic neck pain. Subjects with
chronic nonspecific neck pain were randomly assigned to 12 weeks of group Tai Chi or …