Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents
M Shaquiquzzaman, G Verma, A Marella… - European journal of …, 2015 - Elsevier
Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …
candidates. This ring can be traced in a number of well established, commercially available …
Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders
A Zhang, JL Neumeyer, RJ Baldessarini - Chemical reviews, 2007 - ACS Publications
Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …
[PDF][PDF] Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders
Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …
Synthesis, dopamine D2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl) propyl]-1H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl) ethoxy]-1H …
5-[3-(4-Arylpiperazin-1-yl) propyl]-1H-benzimidazoles and 5-[2-(4-arylpiperazin-1-yl) ethoxy]-
1H-benzimidazoles were synthesized and their affinity for the D1, D2 and 5-HT1A receptors …
1H-benzimidazoles were synthesized and their affinity for the D1, D2 and 5-HT1A receptors …
RP TLC data in correlation studies with in silico pharmacokinetic properties of benzimidazole and benztriazole derivatives
NP Milošević, VB Dimova, NU Perišić-Janjić - European Journal of …, 2013 - Elsevier
Reversed-phase thin-layer chromatographic (RP TLC) retention constants for a newly
designed series benzimidazole/benztriazole with expected biological activity were …
designed series benzimidazole/benztriazole with expected biological activity were …
Synthesis, computational studies and preliminary pharmacological evaluation of 2–[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides as potential …
A series of 2-[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides have been
synthesized and the target compounds (3a–j) were evaluated for atypical antipsychotic …
synthesized and the target compounds (3a–j) were evaluated for atypical antipsychotic …
New Arylpiperazines with Flexible versus Partly Constrained Linker as Serotonin 5‐HT1A/5‐HT7 Receptor Ligands
P Kowalski, K Mitka, J Jaśkowska… - Archiv der …, 2013 - Wiley Online Library
A series of new long‐chain arylpiperazine (LCAP) derivatives with flexible and partly
constrained alkyl linker were synthesized and investigated in vitro as potential serotonin 5 …
constrained alkyl linker were synthesized and investigated in vitro as potential serotonin 5 …
Structure–retention relationship study of arylpiperazines by linear multivariate modeling
A quantitative structure–retention relationship study has been performed to correlate the
retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using …
retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using …
Benzotriazole: Much more than just synthetic heterocyclic chemistry
Benzotriazole could be considered as a premium synthetic auxiliary that has been
extensively explored for the synthesis of natural and synthetic-based molecules of varied …
extensively explored for the synthesis of natural and synthetic-based molecules of varied …
Synthesis and preliminary pharmacological evaluation of 2-[4-(Aryl substituted) piperazin-1-yl]-Nphenylacetamides: potential antipsychotics
Purpose: Arylpiperazines have been recognized as the largest and most diverse class of
compounds exerting actions on the central nervous system with strong affinity for serotonin …
compounds exerting actions on the central nervous system with strong affinity for serotonin …