Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …

Importance The operative scenarios with the highest postoperative pancreatic fistula (POPF)
risk represent situations in which fistula prevention and mitigation strategies have the …

Background Risk factors for the development of clinically relevant POPF (CR-POPF)
following distal pancreatectomy (DP) need clarification particularly following the 2016 …

Approximately 20% of pancreatic ductal adenocarcinoma (PDAC) patients have (borderline)
resectable pancreatic cancer [(B) RPC] at diagnosis. Upfront resection with adjuvant …

Importance In the past decade, the use of neoadjuvant therapy (NAT) has increased for
patients with borderline and locally advanced pancreatic ductal adenocarcinoma (PDAC) …

Multimodal treatment including surgery and chemotherapy is considered the gold standard
treatment of pancreatic cancer by most guidelines. Neoadjuvant therapy (NAT) has been …

Objectives: To investigate the effect of preoperative chemoradiotherapy on surgical
complications in patients after pancreatic resection for (borderline-) resectable pancreatic …

Background Existing postoperative pancreatic fistula risk scores rely on intraoperative
parameters, which limits their value in the preoperative setting. A preoperative predictive …

Background Despite abundant, high-level scientific evidence, there is no consensus
regarding the prevention, mitigation, and management of clinically relevant pancreatic fistula …