[HTML][HTML] Biocatalysis
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …
academia and across the chemical and pharmaceutical industries. Its success has been …
Expanding chemistry through in vitro and in vivo biocatalysis
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …
Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis
Developing synthetically useful enzymatic reactions that are not known in biochemistry and
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …
Genome mining for unknown–unknown natural products
DA Yee, K Niwa, B Perlatti, M Chen, Y Li… - Nature chemical …, 2023 - nature.com
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
β-NAD as a building block in natural product biosynthesis
Abstratct β-Nicotinamide adenine dinucleotide (β-NAD) is a pivotal metabolite for all living
organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of …
organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of …
Infection leaves a genetic and functional mark on the gut population of a commensal bacterium
Gastrointestinal infection changes microbiome composition and gene expression. In this
study, we demonstrate that enteric infection also promotes rapid genetic adaptation in a gut …
study, we demonstrate that enteric infection also promotes rapid genetic adaptation in a gut …
Data science-driven analysis of substrate-permissive diketopiperazine reverse prenyltransferase NotF: applications in protein engineering and cascade biocatalytic …
Prenyltransfer is an early-stage carbon–hydrogen bond (C–H) functionalization prevalent in
the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and …
the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and …
Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids
Fusaric acid (FA) is a well-known mycotoxin that plays an important role in plant pathology.
The biosynthetic gene cluster for FA has been identified, but the biosynthetic pathway …
The biosynthetic gene cluster for FA has been identified, but the biosynthetic pathway …
The structural basis of pyridoxal-5′-phosphate-dependent β-NAD-alkylating enzymes
SbzP is a unique pyridoxal-5′-phosphate-dependent enzyme, which catalyses a [3+ 2]
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …