TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

Vertebrate development begins with precise molecular, cellular, and morphogenetic controls
to establish the basic body plan of the embryo. In zebrafish, these tightly regulated …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Axis specification of the zebrafish embryo begins during oogenesis and relies on proper
formation of well-defined cytoplasmic domains within the oocyte. Upon fertilization …

Soon after fertilization the zebrafish embryo generates the pool of cells that will give rise to
the germline and the three somatic germ layers of the embryo (ectoderm, mesoderm and …

MicroRNAs (miRNAs), as important regulators of post-transcriptional gene expression, play
important roles in the occurrence and function of organs. In this study, morpholino (MO) …

During zebrafish embryogenesis the pronephric kidney arises from a small population of
posterior mesoderm cells that then undergo expansion during early stages of renal …

Background: Vertebrate axis development depends upon wnt8a transcription in a dynamic
pool of mesoderm progenitors at the posterior pole of the gastrulating embryo. The …

Recently, emerging evidence has shown that Stat3 controls tumor cell migration and
invasion. However, the molecular mechanisms by which Stat3 controls the cell movement …

Les mutations du gène AUTS2 humain ont été associé à de nombreuses neuropathologies
tels que des troubles du spectre autistique, un retard global de développement associé à …