PI3K/Akt inhibition promotes AR activity and prostate cancer cell proliferation through p35-CDK5 modulation

WH Kao, KY Chiu, SCS Tsai, CLJ Teng, M Oner… - … et Biophysica Acta (BBA …, 2025 - Elsevier
Abstract Aberrant PI3K/Akt activation is linked to prostate cancer (PCa) malignancy, while
androgen receptor (AR) is critical in early-stage PCa development. Investigating the …

Metformin inhibits nerve growth factor (NGF)-induced sympathetic neuron differentiation through p35/CDK5 inhibition

M Oner, M Chen, PT Cheng… - American Journal of …, 2024 - journals.physiology.org
The authors' previous research has shown the pivotal roles of Cyclin-dependent kinase 5
(CDK5) and its regulatory protein p35 in nerve growth factor (NGF)-induced differentiation of …