In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

Strategies for management of inflammatory bowel diseases are shifting from simple control
of symptoms toward full control of these diseases (clinical and endoscopic remission), with …

The intestinal microflora, typically equated with bacteria, influences diseases such as
obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a …

The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central
feature of the immune response. The extent to which chemokine expression levels are …

Background Lack of evidence-based outcomes data leads to uncertainty in developing
treatment regimens in children who are newly diagnosed with ulcerative colitis. We …

Ulcerative colitis is a common chronic inflammatory disease of the colon and rectum,
resulting from a dysregulated immune response towards intraluminal antigens in a …

The major inflammatory bowel diseases, Crohn's disease and ulcerative colitis, are both
debilitating disorders of the gastrointestinal tract, characterized by a dysregulated immune …

The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF)
consist of approximately 50 membrane and soluble proteins that can modulate cellular …

Background and Aims Causes of inflammatory bowel diseases are not well understood and
the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes …

We are currently in an exciting time when our understanding of genetic underpinnings of
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel …