The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Prokaryotic cell membrane‑based protein technologies

M Suhaib Al Huq, K Raja… - World Academy of …, 2024 - spandidos-publications.com
The biological cell membranes play a crucial role in living tissues through a heterogeneity of
metabolic processes, such as apoptosis, necrosis, autophagy, cell signalling processes and …

Real-time biosynthetic reaction monitoring informs the mechanism of action of antibiotics

AO Oluwole, VM Hernández-Rocamora… - Journal of the …, 2024 - ACS Publications
The rapid spread of drug-resistant pathogens and the declining discovery of new antibiotics
have created a global health crisis and heightened interest in the search for novel …

Online Buffer Exchange Enables Automated Membrane Protein Analysis by Native Mass Spectrometry

W Liu, HS Jayasekera, JD Sanders, G Zhang… - Analytical …, 2023 - ACS Publications
Membrane proteins represent the majority of clinical drug targets and are actively involved in
a range of cellular processes. However, the complexity of membrane mimetics for …

A special issue of Essays in Biochemistry on structural mass spectrometry

HM Britt, R Beveridge, AN Calabrese - Essays in Biochemistry, 2023 - portlandpress.com
Mass spectrometry (MS) is now established as an analytical tool to interrogate the structure
and dynamics of proteins and their assemblies. An array of MS-based technologies has …

Membrane Proteins: Challenging Biotherapeutic Targets

H Jayasekera, FA Mohona, M Marty - 2024 - chemrxiv.org
Membrane proteins are about 30% of the human proteome and serve important
physiological roles, including chemical transport, cell signaling, and energy transduction …