Mouse models are the basis of preclinical and translational research in hepatocellular
carcinoma (HCC). Multiple methods exist to induce tumour formation in mice, including …

Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Since the discovery of the “nude” mouse more than 40 years ago, investigators have
attempted to model human tumor growth in immunodeficient mice. Here, we summarize how …

Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes
and tumor suppressor genes. Despite recent advances in high-throughput sequencing …

The patient-derived xenograft (PDX) model is emerging as a promising translational platform
to duplicate the characteristics of tumours. However, few studies have reported detailed …

Patient-derived xenograft (PDX) models are increasingly being used in oncology drug
development because they offer greater predictive value than traditional cell line models …

Resistance mechanisms and heterogeneity in HER2-positive gastric cancers (GC) limit
Trastuzumab benefit in 32% of patients, and other targeted therapies have failed in clinical …

Patient-derived xenograft (PDX) tumor models have emerged as a new approach to
evaluate the effects of cancer drugs on patients' personalized tumor grafts enabling to select …

Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic
regimes, which are largely unsuccessful in advanced patients. Preclinical models are …

A significant obstacle to the study of human cancer biology and the testing of human specific
immunotherapeutics is the paucity of translational models that recapitulate both the growth …