All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

Mitochondria, organelles that harbor their own circular genomes, are critical for energy
production and homeostasis maintenance in eukaryotic cells. Recent studies discovered …

Mitochondria participate in a wide range of cellular processes. One essential function of
mitochondria is to be a platform for antiviral signaling proteins during the innate immune …

Mitochondria are essential regulators of innate immunity. They generate long mitochondrial
double-stranded RNAs (mt-dsRNAs) and release them into the cytosol to trigger an immune …

The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and
activation of repetitive elements in the genome. The transcription of endogenous …

In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop
interacting RNA-binding protein (SLIRP) form a complex in the mitochondrial matrix that is …

Perturbations of mitochondrial proteostasis have been associated with aging,
neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia …

Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common
feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer incidence …

The human mitochondrial genome (mtDNA) regulates its transcription products in
specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA …

Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …