Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment
I Pomytkin, JP Costa‐Nunes, V Kasatkin… - CNS neuroscience & …, 2018 - Wiley Online Library
While the insulin receptor (IR) was found in the CNS decades ago, the brain was long
considered to be an insulin‐insensitive organ. This view is currently revisited, given …
considered to be an insulin‐insensitive organ. This view is currently revisited, given …
The expression of insulin in the central nervous system: What have we learned so far?
After being discovered over a century ago, insulin was long considered to be a hormone
exclusively produced by the pancreas. Insulin presence was later discovered in the brain …
exclusively produced by the pancreas. Insulin presence was later discovered in the brain …
An acute microglial metabolic response controls metabolism and improves memory
Chronic high-fat feeding triggers metabolic dysfunction including obesity, insulin resistance,
and diabetes. How high-fat intake first triggers these pathophysiological states remains …
and diabetes. How high-fat intake first triggers these pathophysiological states remains …
Dysmetabolism and neurodegeneration: trick or treat?
AM Capucho, A Chegão, FO Martins… - Nutrients, 2022 - mdpi.com
Accumulating evidence suggests the existence of a strong link between metabolic syndrome
and neurodegeneration. Indeed, epidemiologic studies have described solid associations …
and neurodegeneration. Indeed, epidemiologic studies have described solid associations …
[HTML][HTML] Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production
Evidence has mounted that insulin can be synthesized in various brain regions, including
the hypothalamus. However, the distribution and functions of insulin-expressing cells in the …
the hypothalamus. However, the distribution and functions of insulin-expressing cells in the …
Quo vadis PGRMC? Grand-scale biology in human health and disease
MA Cahill - Frontiers in Bioscience-Landmark, 2022 - researchoutput.csu.edu.au
The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …
from where 'did you come?'posed in the accompanying paper and extends consideration of …
Dietary restriction alters insulin signaling pathway in the brain
S Todorovic, V Simeunovic, M Prvulovic, T Dakic… - …, 2024 - Wiley Online Library
Insulin is known to be a key hormone in the regulation of peripheral glucose homeostasis,
but beyond that, its effects on the brain are now undisputed. Impairments in insulin signaling …
but beyond that, its effects on the brain are now undisputed. Impairments in insulin signaling …
Early adversity and insulin: neuroendocrine programming beyond glucocorticoids
Exposure to direct or contextual adversities during early life programs the functioning of the
brain and other biological systems, contributing to the development of physical as well as …
brain and other biological systems, contributing to the development of physical as well as …
Food for thought: short-term fasting upregulates glucose transporters in neurons and endothelial cells, but not in astrocytes
Our group previously reported that 6-h fasting increased both insulin II mRNA expression
and insulin level in rat hypothalamus. Given that insulin effects on central glucose …
and insulin level in rat hypothalamus. Given that insulin effects on central glucose …
Hypothalamic insulin expression remains unaltered after short-term fasting in female rats
Purpose Our previous study showed that 6-h fasting increased insulin expression in the
hypothalamus of male rats. We, therefore, wanted to examine if this phenomenon occurs in …
hypothalamus of male rats. We, therefore, wanted to examine if this phenomenon occurs in …