Background Immunotherapy targeting the PD-1 axis has activity in several tumour types. We
aimed to establish the activity and safety of the PD-1 inhibitor pembrolizumab in patients …

Brain metastasis is the most common intracranial tumor in adults. Currently, treatment of
brain metastasis requires multidisciplinary approach tailored for each individual patient …

Background Significant progress has been made in the treatment of selected malignancies
with immune-modulating antibodies. Phase III trials of anti-CTLA-4 in melanoma and anti-PD …

Object To evaluate the role of stereotactic radiosurgery (SRS) in the management of brain
metastases from melanoma, the authors assessed clinical outcomes and prognostic factors …

Purpose Stereotactic radiosurgery (SRS) in combination with immunotherapy (IMT) or
targeted therapy is increasingly being used in the setting of melanoma brain metastases …

Simple Summary Non-small cell lung cancer (NSCLC) is the most common cause of brain
metastasis (BM). Approximately 50% of patients with metastatic NSCLC harbor BMs. Within …

The number of patients who develop metastatic brain lesions is increasing as the diagnosis
and treatment of systemic cancers continues to improve, resulting in longer patient survival …

Object Intra-tumoral hemorrhage is considered an imaging characteristic of advanced
cancer disease. However, data on the influence of intra-tumoral hemorrhage in patients with …

Background Few safety data of concurrent stereotactic radiosurgery and targeted therapy
(TT) or immunotherapy (IT) are available. The aim of the study was to evaluate the outcome …

In the present study, we have evaluated the efficacy and toxicity of repeated brain
metastases (BM) stereotactic radiosurgery (SRS2) following local failure of a prior …